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p-Coumaric acid stimulates longitudinal bone growth through increasing the serum production and expression levels of insulin-like growth factor 1 in rats

Lee, Jong Hyuk, Chung, Yoon Hee, Kim, Ho Hyun, Bang, Joon Seok, Jung, Tae Woo, Park, Taekwang, Park, Jinwoo, Kim, Uiseok, Lee, Sung Hoon, Jeong, Ji Hoon
Biochemical and biophysical research communications 2018
adolescents, blood serum, cell proliferation, growth plate, hormone replacement therapy, insulin-like growth factor I, males, p-coumaric acid, rats, somatotropin, tibia
The aim of the present study was to examine the effects of p-coumaric acid on the longitudinal growth of the long bone in adolescent male rats. Teatment with p-coumaric acid significantly increased the tibial length and the height of each growth plate zone and the ratio of 5-bromo-2′-deoxyuridine-positive cells relative to total proliferative cells. Expression of insulin-like growth factor 1 and its receptor in the proliferative and hypertrophic zones, and serum levels of growth hormone and insulin-like growth factor 1 were significantly increased as well in the p-coumaric acid-treated group. Via increasing both the serum level of insulin-like growth factor 1 and its expression, p-coumaric acid could promote cell proliferation in growth plate zones. These results suggest that p-coumaric acid has the potential to increase height and may be a feasible alternative to growth hormone therapy.