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p-Coumaric acid stimulates longitudinal bone growth through increasing the serum production and expression levels of insulin-like growth factor 1 in rats
- Lee, Jong Hyuk, Chung, Yoon Hee, Kim, Ho Hyun, Bang, Joon Seok, Jung, Tae Woo, Park, Taekwang, Park, Jinwoo, Kim, Uiseok, Lee, Sung Hoon, Jeong, Ji Hoon
- Biochemical and biophysical research communications 2018
- adolescents, blood serum, cell proliferation, growth plate, hormone replacement therapy, insulin-like growth factor I, males, p-coumaric acid, rats, somatotropin, tibia
- The aim of the present study was to examine the effects of p-coumaric acid on the longitudinal growth of the long bone in adolescent male rats. Teatment with p-coumaric acid significantly increased the tibial length and the height of each growth plate zone and the ratio of 5-bromo-2′-deoxyuridine-positive cells relative to total proliferative cells. Expression of insulin-like growth factor 1 and its receptor in the proliferative and hypertrophic zones, and serum levels of growth hormone and insulin-like growth factor 1 were significantly increased as well in the p-coumaric acid-treated group. Via increasing both the serum level of insulin-like growth factor 1 and its expression, p-coumaric acid could promote cell proliferation in growth plate zones. These results suggest that p-coumaric acid has the potential to increase height and may be a feasible alternative to growth hormone therapy.