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A convenient and mild cyclocondensation using water-soluble aldehydes in water
- Kitanosono, Taku, Cho, Soo Min, Kobayashi, Shū
- Tetrahedron 2018 v.74 no.51 pp. 7237-7241
- aldehydes, byproducts, cations, chemical reactions, chemical structure, water solubility
- The use of negatively charged aluminosilicate layers and Lewis acidic cations embedded therein allowed efficient cyclocondensation of bisamines with water-soluble aldehydes to be achieved in water. The protocol does not involve acidic or reflux conditions, thereby avoiding undesired byproduct formation. The use of water as a reaction medium is indispensable to ensure high reaction yields.