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Development of bacterial cellulose/chitosan based semi-interpenetrating hydrogels with improved mechanical and antibacterial properties

Author:
Wahid, Fazli, Hu, Xiao-Hui, Chu, Li-Qiang, Jia, Shi-Ru, Xie, Yan-Yan, Zhong, Cheng
Source:
International journal of biological macromolecules 2019 v.122 pp. 380-387
ISSN:
0141-8130
Subject:
Fourier transform infrared spectroscopy, Gram-negative bacteria, X-ray diffraction, antibacterial properties, cellulose, chitosan, crosslinking, freeze drying, glutaraldehyde, hydrogels, mechanical properties, mixing, porous media, rheometry, scanning electron microscopy, slurries, thermal stability, thermogravimetry
Abstract:
In the present work, novel bacterial cellulose (BC) and chitosan (CS) semi-interpenetrating network (semi-IPN) hydrogels were prepared via blending the slurry of BC with CS solution followed by cross-linking with glutaraldehyde. The structure and properties of BC-CS hydrogels were characterized by different techniques including; FTIR, XRD, FE-SEM, TGA and rotational rheometry. The results indicated cross-linking of chitosan chains by glutaraldehyde while BC was physically connected to network forming semi-IPN hydrogels. Microscopic study of cross-sectional freeze-dried hydrogels showed microporous openings. BC-CS hydrogels exhibited higher thermal stability than pure BC film or CS hydrogel alone. The rheological results presented significant mechanical properties of semi-IPN hydrogels. Moreover, the hydrogels showed antibacterial properties against tested Gram-positive and Gram-negative bacteria. The antibacterial properties were dependent on the ratio of BC to CS. Hydrogels with 20% BC to CS reduced the viable colonies by ~88%. The development of this new class of BC-CS antibacterial, mechanically strong and stable soft-material could be a promising candidate for antibacterial applications.
Agid:
6176716