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Development of bacterial cellulose/chitosan based semi-interpenetrating hydrogels with improved mechanical and antibacterial properties

Wahid, Fazli, Hu, Xiao-Hui, Chu, Li-Qiang, Jia, Shi-Ru, Xie, Yan-Yan, Zhong, Cheng
International journal of biological macromolecules 2019 v.122 pp. 380-387
Fourier transform infrared spectroscopy, Gram-negative bacteria, X-ray diffraction, antibacterial properties, cellulose, chitosan, crosslinking, freeze drying, glutaraldehyde, hydrogels, mechanical properties, mixing, porous media, rheometry, scanning electron microscopy, slurries, thermal stability, thermogravimetry
In the present work, novel bacterial cellulose (BC) and chitosan (CS) semi-interpenetrating network (semi-IPN) hydrogels were prepared via blending the slurry of BC with CS solution followed by cross-linking with glutaraldehyde. The structure and properties of BC-CS hydrogels were characterized by different techniques including; FTIR, XRD, FE-SEM, TGA and rotational rheometry. The results indicated cross-linking of chitosan chains by glutaraldehyde while BC was physically connected to network forming semi-IPN hydrogels. Microscopic study of cross-sectional freeze-dried hydrogels showed microporous openings. BC-CS hydrogels exhibited higher thermal stability than pure BC film or CS hydrogel alone. The rheological results presented significant mechanical properties of semi-IPN hydrogels. Moreover, the hydrogels showed antibacterial properties against tested Gram-positive and Gram-negative bacteria. The antibacterial properties were dependent on the ratio of BC to CS. Hydrogels with 20% BC to CS reduced the viable colonies by ~88%. The development of this new class of BC-CS antibacterial, mechanically strong and stable soft-material could be a promising candidate for antibacterial applications.