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Preparation and characterization of D. opposita Thunb polysaccharide-zinc inclusion complex and evaluation of anti-diabetic activities

Author:
Zhang, Yun, Khan, M.Z.H., Yuan, Tingting, Zhang, Yuwei, Liu, Xiuhua, Du, Zuliang, Zhao, Yingyong
Source:
International journal of biological macromolecules 2019 v.121 pp. 1029-1036
ISSN:
0141-8130
Subject:
Dioscorea oppositifolia, animal disease models, blood serum, diabetes, functional foods, glucose, glycemic effect, ingredients, insulin, liver, malondialdehyde, polysaccharides, rats, spectroscopy, streptozotocin, superoxide dismutase, zinc
Abstract:
In the present work, Dioscorea opposita Thunb polysaccharide-zinc (DPS-zinc) inclusion complex was synthesized for the first time and its anti-diabetes activities against Streptozotocin (STZ)-induced diabetic rats were assayed. The detail structural and morphological analysis of as-prepared DPS-zinc complex was done by using different spectroscopic and microscopic methods. The pharmacological study revealed that DPS-zinc presented a potent hypoglycemic effect on STZ-induced diabetic rats, decreased the glucose and insulin levels, reduced malondialdehyde (MDA) contents and increased SOD and T-AOC activities significantly in liver. The levels of T-CHO, TG and LDL-C in serum were dramatically decreased while HDL-C level was increased with the treatment of proposed inclusion complex. In brief, DPS-zinc could be considered as a potential candidate for developing an ingredient of functional foods for zinc supplements with the hypoglycemic action.
Agid:
6176719