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Preparation and characterization of D. opposita Thunb polysaccharide-zinc inclusion complex and evaluation of anti-diabetic activities

Zhang, Yun, Khan, M.Z.H., Yuan, Tingting, Zhang, Yuwei, Liu, Xiuhua, Du, Zuliang, Zhao, Yingyong
International journal of biological macromolecules 2019 v.121 pp. 1029-1036
Dioscorea oppositifolia, animal disease models, blood serum, diabetes, functional foods, glucose, glycemic effect, ingredients, insulin, liver, malondialdehyde, polysaccharides, rats, spectroscopy, streptozotocin, superoxide dismutase, zinc
In the present work, Dioscorea opposita Thunb polysaccharide-zinc (DPS-zinc) inclusion complex was synthesized for the first time and its anti-diabetes activities against Streptozotocin (STZ)-induced diabetic rats were assayed. The detail structural and morphological analysis of as-prepared DPS-zinc complex was done by using different spectroscopic and microscopic methods. The pharmacological study revealed that DPS-zinc presented a potent hypoglycemic effect on STZ-induced diabetic rats, decreased the glucose and insulin levels, reduced malondialdehyde (MDA) contents and increased SOD and T-AOC activities significantly in liver. The levels of T-CHO, TG and LDL-C in serum were dramatically decreased while HDL-C level was increased with the treatment of proposed inclusion complex. In brief, DPS-zinc could be considered as a potential candidate for developing an ingredient of functional foods for zinc supplements with the hypoglycemic action.