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Tumor-microenvironment controlled nanomicelles with AIE property for boosting cancer therapy and apoptosis monitoring

Author:
Qian, Yixia, Wang, Yuehua, Jia, Fei, Wang, Zihua, Yue, Chunyan, Zhang, Weikai, Hu, Zhiyuan, Wang, Weizhi
Source:
Biomaterials 2019 v.188 pp. 96-106
ISSN:
0142-9612
Subject:
acidity, animal tissues, apoptosis, biomarkers, blood circulation, blood vessels, drug delivery systems, drugs, fluorescence, genes, image analysis, micelles, moieties, monitoring, nanoparticles, neoplasms, pH, precision medicine, sequence analysis
Abstract:
Mild acidity matrix, rich blood vessels and special biomarkers constitute the primary tumor microenvironment. Nanoparticles could change their physicochemical characteristics by functionalizing a series of moieties which is responsive towards pH or specific markers. So precise regulation of nanocarrier-based drug delivery systems by the tumor microenvironment has showed great potential for theranostics. Herein, we developed a smart nano delivery system STD-NM, showing tumor microenvironment responsive targeting, efficient drug delivery and precise evaluation of therapeutic effect in vivo. STD-NM kept in ‘stealth’ state in normal environment while ‘activated’ in the tumor acidic environment, which could show stability in blood circulation while deeply penetrate into tumor tissues. Additionally, STD-NM was designed with aggregation-induced emission (AIE) characteristic, of which the fluorescence ‘switch on’ when apoptosis taken place. Gene analysis by RNA-seq also confirmed a superior therapeutic effect of drug loaded STD-NM treatment. We envisioned the well-designed smart nano materials for drug delivery could open a new avenue in precisely tumor imaging and specific cancer therapeutics.
Agid:
6176752