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Modification of oligodeoxynucleotides by on-column Suzuki cross-coupling reactions

Author:
Ejlersen, Maria, Lou, Chenguang, Sanghvi, Yogesh S., Tor, Yitzhak, Wengel, Jesper
Source:
Chemical communications 2018 v.54 no.57 pp. 8003-8006
ISSN:
1364-548X
Subject:
Suzuki reaction, boronic acids, oligodeoxyribonucleotides
Abstract:
The on-column functionalization of oligodeoxynucleotides via base-free Suzuki cross-coupling reactions is reported herein. These cross-coupling reactions were carried out with various boronic acids and either full-length modified oligonucleotides containing one or more 2′-deoxy-5-iodouridine (5IdU) monomer(s) or on oligonucleotide fragments immediately after incorporation of 5IdU. Five different functionalities were coupled to oligonucleotides containing one or three attachment points.
Agid:
6177534