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Nucleus-targeted DNA tetrahedron as a nanocarrier of metal complexes for enhanced glioma therapy

Author:
TianThese authors contributed equally to the work., Yiqiao, Huang, Yanyu, Gao, Pan, Chen, Tianfeng
Source:
Chemical communications 2018 v.54 no.68 pp. 9394-9397
ISSN:
1364-548X
Subject:
DNA, cell nucleus, chemical reactions, glioma, metals, nanocarriers, signal transduction
Abstract:
A negatively-charged and nucleus-targeted DNA tetrahedron is rationally designed and used as a nanocarrier of positively-charged metal complexes. This tetrahedron speeds up the translocation of metal complexes into the cell nucleus, and inhibits the growth and invasion of glioma cells by triggering vascular mimicry-associated signaling pathways, thus achieving precise glioma treatment.
Agid:
6177706