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Copper-catalyzed decarboxylative propargylation/hydroamination reactions: access to C3 β-ketoester-functionalized indoles

Author:
Wang, Sasa, Liu, Miao, Chen, Xinzheng, Wang, Huifei, Zhai, Hongbin
Source:
Chemical communications 2018 v.54 no.60 pp. 8375-8378
ISSN:
1364-548X
Subject:
catalytic activity, chemical reactions, copper, indoles, structure-activity relationships, synthesis
Abstract:
A copper-catalyzed reaction of ethynyl benzoxazinanones with readily accessible β-ketoesters via a decarboxylative propargylation/hydroamination sequence has been developed. This protocol furnished a diverse range of C3 β-ketoester-functionalized indoles in good to excellent yields.
Agid:
6177823