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Csp³–H bond functionalization of amines via tunable iminium ions: divergent synthesis of trifluoromethylated arylamines

Author:
Shi, Lou, Wang, Mingshan, Pan, Ling, Li, Yifei, Liu, Qun
Source:
Chemical communications 2018 v.54 no.63 pp. 8721-8724
ISSN:
1364-548X
Subject:
amines, ions, isomerization, regioselectivity
Abstract:
A series of tunable iminium ions, generated in situ by the condensation of 4-trifluoromethyl-p-quinols with cyclic amines, can lead to the divergent synthesis of trifluoromethylated arylamines in a single step via redox-neutral isomerization. The direct α- and β-functionalization of saturated amines can be achieved regioselectively under mild conditions.
Agid:
6177906