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Chiral Lewis acid-catalyzed enantioselective cyclopropanation and C–H insertion reactions of vinyl ketones with α-diazoesters

Author:
Zhao, Peng, Wu, Simeng, Ke, Chaoqi, Liu, Xiaohua, Feng, Xiaoming
Source:
Chemical communications 2018 v.54 no.70 pp. 9837-9840
ISSN:
1364-548X
Subject:
catalysts, chemical reactions, enantioselectivity, ketones
Abstract:
Enantioselective cyclopropanation and C–H insertion reactions of α-substituted vinyl ketones with α-diazoesters have been accomplished using a N,N′-dioxide-scandium(iii) complex catalyst. Various tetrasubstituted cyclopropanes and E-enone derivatives bearing a chiral ester substituent were obtained simultaneously with good yields and excellent enantioselectivities.
Agid:
6177990