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Synthesis of new fluorinated proline analogues from polyfluoroalkyl β-ketoacetals and ethyl isocyanoacetate

Author:
Tolmachova, Nataliya A., Kondratov, Ivan S., Dolovanyuk, Violetta G., Pridma, Stanislav O., Chernykh, Anton V., Daniliuc, Constantin G., Haufe, Günter
Source:
Chemical communications 2018 v.54 no.69 pp. 9683-9686
ISSN:
1364-548X
Subject:
chemical compounds, chemical reactions, proline
Abstract:
The reaction of trifluoroaldol acetal and other polyfluoroalkyl β-ketoacetals with ethyl isocyanoacetate was applied for the preparation of hitherto unknown fluorinated amino acids, cis- and trans-3-CF₃/C₂F₅-prolines as well as trans-3-CF₂Br/CF₂Cl/CHF₂-3-hydroxyprolines.
Agid:
6178031