Jump to Main Content
Synthesis of new fluorinated proline analogues from polyfluoroalkyl β-ketoacetals and ethyl isocyanoacetate
- Tolmachova, Nataliya A., Kondratov, Ivan S., Dolovanyuk, Violetta G., Pridma, Stanislav O., Chernykh, Anton V., Daniliuc, Constantin G., Haufe, Günter
- Chemical communications 2018 v.54 no.69 pp. 9683-9686
- chemical compounds, chemical reactions, proline
- The reaction of trifluoroaldol acetal and other polyfluoroalkyl β-ketoacetals with ethyl isocyanoacetate was applied for the preparation of hitherto unknown fluorinated amino acids, cis- and trans-3-CF₃/C₂F₅-prolines as well as trans-3-CF₂Br/CF₂Cl/CHF₂-3-hydroxyprolines.