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Novel caged luciferin derivatives can prolong bioluminescence imaging in vitro and in vivo

Author:
Zhang, Chaochao, Yuan, Mingliang, Han, Guangxi, Gao, Yuqi, Tang, Chunchao, Li, Xiang, Du, Lupei, Li, Minyong
Source:
RSC advances 2018 v.8 no.35 pp. 19596-19599
ISSN:
2046-2069
Subject:
bioluminescence, cytotoxicity, image analysis, luciferase, luciferin
Abstract:
Based on N-cyclobutylaminoluciferin (cybLuc), a set of high and efficient caged bioluminescent derivatives (Clucs) as firefly luciferase pro-substrates has been developed herein. After careful examination, these molecules exhibited low cytotoxicity and prolonged bioluminescence imaging up to 6 h in vitro and in vivo. Importantly, these caged luciferin derivatives have the potential to serve as long-term tracking tools to explore some biological process by using bioluminescent imaging.
Agid:
6183923