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Hepatoprotective effects of selenium-biofortified soybean peptides on liver fibrosis induced by tetrachloromethane

Liu, Weiwei, Hou, Tao, Shi, Wen, Guo, Danjun, He, Hui
Journal of functional foods 2018 v.50 pp. 183-191
actin, alanine transaminase, aspartate transaminase, blood serum, carbon tetrachloride, fibrosis, gelatinase B, gene expression, glutathione, glutathione peroxidase, hepatoprotective effect, histology, liver, liver cirrhosis, messenger RNA, muscles, rats, soybeans
The aim of this study was to investigate the hepatoprotective effects of selenium-biofortified soybean peptides (SSPs) in liver fibrosis induced by tetrachloromethane (CCl4) in rats. SSPs was found to remarkably attenuate the liver fibrosis by inhibiting α-smooth muscle actin (α-SMA) synthesis in the liver, and increasing the mRNA expression of matrix metalloproteinase 9 (MMP9). Additionally, aspartate transaminase (AST) and alanine aminotransferase (ALT) activities in serum decreased, while the glutathione (GSH) content and the glutathione peroxidase (GSH-Px) activity increased significantly (p < 0.05) after the treatment with SSPs. Histology results showed that both inflammatory cell infiltration and fibrosis area were decreased by SSPs treatment. SeCys, which was the active center of GSH-Px, was identified in some Se-peptides from SSPs. Thus, SSPs can attenuate the liver fibrosis induced by CCl4 by improving the GSH-Px synthesis and increasing the MMP9 mRNA expression level.