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Heat shock protein-guided dual-mode CT/MR imaging of orthotopic hepatocellular carcinoma tumor

Author:
WangRuizhi Wang, Yu Luo and Xin Li contributed equally to this work., Ruizhi, Luo, Yu, Li, Xin, Ji, Aihua, Guo, Rongfang, Shi, Xiangyang, Wang, Xiaolin
Source:
Journal of materials chemistry 2018 v.6 no.9 pp. 1342-1350
ISSN:
2050-7518
Subject:
X-radiation, chemistry, computed tomography, gadolinium, heat stress, heat-shock protein 90, hepatoma, image analysis, models, nanogold, neoplasm cells, polyethyleneimine
Abstract:
The development of an ultrasensitive nanoprobe is regarded as one of the most promising strategies for the precise diagnosis of tumors. Herein, tanespimycin (17-AAG)-modified polyethylenimine-based gold nanoparticles (AuNPs) co-labeled with a gadolinium (Gd) nanoprobe are constructed for targeted dual-mode computed tomography (CT)/magnetic resonance (MR) imaging. The specific binding of tanespimycin to the N-terminal of heat shock protein 90 (HSP90) endows the modified nanoprobes (NPs) with the ability to up-regulate HSP90 tumor cells and to display excellent X-ray attenuation intensity and T₁ MR imaging performance in an orthotopic hepatocellular carcinoma tumor model. Such an ultrasensitive nanoprobe holds enormous promise for highly efficient tumor diagnosis and dual-mode CT/T₁ positive MR imaging. This study develops a novel strategy to prepare a multifunctional nanoprobe via polyethylenimine nanotechnology. Using this strategy, various dual-mode or multimode nanoprobes for diagnosing different cancers may be designed.
Agid:
6185573