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A convenient approach to difluoromethylated all-carbon quaternary centers via Ni(ii)-catalyzed enantioselective Michael addition

Author:
Yu, Xuan, Bai, Hui, Wang, Dong, Qin, Zhaohai, Li, Jia-Qi, Fu, Bin
Source:
RSC advances 2018 v.8 no.35 pp. 19402-19408
ISSN:
2046-2069
Subject:
chemical reactions, enantioselectivity, nickel, nitroalkenes, protocols
Abstract:
A Ni(ii)-catalyzed enantioselective Michael addition of 2-acetyl azarenes with β-difluoromethyl substituted nitroalkenes was successfully realized, which afforded chiral CF₂H-containing compounds in good enantioselectivities (up to 93% ee). This protocol provides a new convenient approach to all-carbon quaternary stereogenic centers featuring a CF₂H group.
Agid:
6185723