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Gadolinium-labelled iron/iron oxide core/shell nanoparticles as T₁–T₂ contrast agent for magnetic resonance imaging

Wang, Kaili, An, Lu, Tian, Qiwei, Lin, Jiaomin, Yang, Shiping
RSC advances 2018 v.8 no.47 pp. 26764-26770
cytotoxicity, gadolinium, image analysis, iron, iron oxides, magnetic resonance imaging, nanoparticles, risk
Magnetic resonance imaging (MRI) is indispensable and powerful in modern clinical diagnosis and has some advantages such as non-invasiveness and high penetration depth. Furthermore, dual T₁–T₂ MR imaging has attracted crucial interest as it can decrease the risk of pseudo-positive signals in diagnosing lesions. And it's worth nothing that the dual-mode MR imaging displays a vital platform to provide relatively comprehensive diagnosis information and receive accurate results. Herein, we report a dual T₁–T₂ MR imaging contrast agent (CA) grounded on the iron/iron oxide core/shell nanomaterials conjugated with gadolinium chelate. The Gd-labeled Fe@Fe₃O₄ NPs reveal the feasibility to utilize them to serve as a dual T₁–T₂ MR imaging CA, and the relaxivity results in a 0.5 T MR system showed a longitudinal relaxivity value (r₁) and transverse relaxivity value (r₂) of 7.2 mM⁻¹ s⁻¹ and 109.4 mM⁻¹ s⁻¹, respectively. The MTT results demonstrate the Gd-labeled Fe@Fe₃O₄ NPs have no obvious cytotoxicity and a good compatibility. The in vitro and in vivo MRI generated a brighter effect and darkening in T₁-weighted MR imaging and T₂-weighted images, respectively. The results clearly indicate that Gd-labeled Fe@Fe₃O₄ NPs have potential as a magnetic resonance imaging contrast reagent.