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Robust microfluidic construction of hybrid microfibers based on konjac glucomannan and their drug release performance

Ni, Yongsheng, Lin, Wanmei, Mu, Ruo-Jun, Wu, Chunhua, Wang, Lin, Wu, Dan, Chen, Su, Pang, Jie
RSC advances 2018 v.8 no.47 pp. 26432-26439
antibacterial properties, drugs, enrofloxacin, heat tolerance, hydrophilicity, hydrophobicity, konjac mannan, methanol, thermoplastics, tissue repair
The exploration of methods to produce a novel wound dressing with sustained drug release properties in ultrasmall scales is of great scientific and technological interest. Herein, we propose konjac glucomannan/polyvinylidene fluoride (KGM/PVDF) hybrid microfibers having hydrophilic and hydrophobic segments based on microfluidic-oriented core–sheath composite microfibers, where the KGM/PVDF hybrid microfibers are wrapped in situ in CH₃OH. The morphology of KGM/PVDF microfibers is uniform, smooth, and crack-free. Enrofloxacin (Enro) is loaded onto the microfibers as a representative cargo to test their release performance. The KGM/PVDF/Enro microfibers show sustained drug release performance (13 days), excellent heat resistance, antibacterial activity and promotion of wound healing. This study is an avenue toward the microfluidic design of hydrophilic/hydrophobic hybrid microfibers as wound dressings, and it will guide the development of next-generation wound dressing.