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Janus nanocarriers for magnetically targeted and hyperthermia-enhanced curcumin therapy of liver cancer

Xing, Hao, Wang, Zheng, Shao, Dan, Chang, Zhimin, Ge, Mingfeng, Li, Li, Wu, Mingdi, Yan, Zhuangzhi, Dong, Wenfei
RSC advances 2018 v.8 no.53 pp. 30448-30454
antineoplastic activity, bioavailability, biosafety, curcumin, drug therapy, fever, liver neoplasms, magnetic fields, nanocarriers, nanoparticles, porous media, silica, synergism
Curcumin is regarded as a promising chemotherapeutic agent due to its anti-cancer activity and excellent biosafety. Nevertheless, the poor bioavailability and insufficient therapeutic efficacy have limited its further application in the clinic. Hence, we designed Janus magnetic mesoporous silica nanoparticles (Janus M-MSNs) for magnetically targeted and hyperthermia-enhanced curcumin treatment of liver cancer. In this study, curcumin was loaded into the silica components of Janus M-MSNs via surface-decorated pH-sensitive groups. Janus M-MSNs-Cur exhibited superior superparamagnetic properties, high curcumin loading ability and a tumor microenvironment-responsive curcumin release fashion. Additionally, an external magnetic field promoted the anti-tumor effectiveness of Janus M-MSNs-Cur through increasing the cellular internalization of Janus M-MSNs-Cur. More importantly, magnetic hyperthermia therapy supplemented the chemotherapeutic effect through a synergistic effect. Our outcomes demonstrated that Janus M-MSNs-Cur possessed a high therapeutic efficiency and excellent biosafety both in vitro and in vivo, indicating that Janus M-MSNs-Cur might be a promising therapeutic agent for liver cancer treatment.