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Marriage of artificial catalase and black phosphorus nanosheets for reinforced photodynamic antitumor therapy
- Ouyang, Jiang, Deng, Yuanyuan, Chen, Wansong, Xu, Qunfang, Wang, Liqiang, Liu, Zhenjun, Tang, Feiying, Deng, Liu, Liu, You-Nian
- Journal of materials chemistry 2018 v.6 no.14 pp. 2057-2064
- antineoplastic activity, catalase, chemistry, hydrogen peroxide, hypoxia, nanoparticles, nanosheets, neoplasms, phosphorus, semiconductors, therapeutics
- Two dimensional (2D) semiconducting nanomaterials have shown great potential for antitumor therapy. However, their clinical applications are seriously hampered by the tumour microenvironments. Bearing this in mind, we propose to improve the performance of 2D semiconducting nanomaterials using artificial catalase. In this work, we decorate black phosphorus (BP) nanosheets with Pt nanoparticles (NPs) through an in situ growth strategy. Pt NPs as artificial catalases can efficiently decompose the accumulated H₂O₂ in tumours to relieve tumour hypoxia, and thereafter improve the photodynamic antitumor activity of BP nanosheets. This work paves a new avenue for the functionalization of 2D semiconducting nanomaterials, which will promote the development of 2D semiconductor based nanodrugs.