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Nickel-catalysed alkylation of C(sp³)–H bonds with alcohols: direct access to functionalised N-heteroaromatics

Author:
VellakkaranThese authors contributed equally to this work., Mari, Das, Jagadish, Bera, Sourajit, Banerjee, Debasis
Source:
Chemical communications 2018 v.54 no.87 pp. 12369-12372
ISSN:
1364-548X
Subject:
alcohols, alkylation, catalytic activity
Abstract:
The first base-metal catalysed coupling of primary alcohols with methyl-N-heteroaromatics is reported. The use of an earth abundant and nonprecious NiBr₂/L1 system enables access to a series of C(sp³)-alkylated N-heteroaromatics. Mechanistic studies have established the participation of a hydrogen-borrowing strategy for α-alkylation.
Agid:
6192353