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Intramolecular interaction suggests an autosuppression mechanism for the innate immune adaptor protein MyD88
- Uno, Masatoshi, Watanabe-Nakayama, Takahiro, Konno, Hiroki, Akagi, Ken-ichi, Tsutsumi, Naotaka, Fukao, Toshiyuki, Shirakawa, Masahiro, Ohnishi, Hidenori, Tochio, Hidehito
- Chemical communications 2018 v.54 no.87 pp. 12318-12321
- chemical compounds, chemical reactions, innate immunity
- MyD88 (myeloid differentiation factor 88) is an important protein in innate immunity. Two structural domains of MyD88 have been well characterized separately, but the global architecture of full-length MyD88 remained unclear. Here, we propose an autosuppressive mechanism of MyD88 regulated by the intramolecular interaction between the two domains.