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Balancing antimicrobial performance with hemocompatibility in amphiphilic homopolymers

Author:
Zhu, Zhiyuan, Jeong, Gookyeong, Kim, Seung‐Jin, Gadwal, Ikhlas, Choe, Youngson, Bang, Joona, Oh, Min‐Kyu, Khan, Anzar, Rao, Jingyi
Source:
Journal of polymer science 2018 v.56 no.21 pp. 2391-2396
ISSN:
0887-624X
Subject:
antibacterial properties, biocompatibility, composite polymers, free radicals, polyethylene glycol, polymerization, polymethylmethacrylate, protocols
Abstract:
This work establishes amphiphilic polymethacrylates as new antimicrobial candidates that can be synthesized through a combination of controlled free radical polymerization and sequential postpolymerization modification protocols. When conjugated with a polyethylene glycol segment, the block copolymers exhibit a balanced performance between high antibacterial activity and high hemocompatibility.
Agid:
6198259