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Design, synthesis and evaluation of anti-inflammatory, analgesic and antibacterial activity of 2, 4, 6-trisubstituted quinazoline derivatives

Author:
Jain, Nivrati, Jain, Harshita, Jain, Ashish, Ravichandran, Veerasamy, Jain, Prateek
Source:
Analele Universității "Ovidius" Constanța 2018 v.29 no.2 pp. 97-102
ISSN:
2286-038X
Subject:
Escherichia coli, Fourier transform infrared spectroscopy, Gram-negative bacteria, Pseudomonas aeruginosa, Staphylococcus aureus, analgesic effect, analgesics, anti-inflammatory activity, antibacterial properties, antibiotics, indomethacin, mass spectrometry, nuclear magnetic resonance spectroscopy
Abstract:
We described here the synthesis and biological evaluation of a series of 2, 4, 6-trisubstituted quinazoline derivatives as potential anti-inflammatory, analgesic and antibacterial agents. The synthesized compounds were characterized by FTIR, 1H NMR and mass spectroscopy analysis. We found that the compounds 6b, 6e, 6g, 6h and 6j showed better anti-inflammatory activity than indomethacin. Compounds 6b, 6e, 6h, 6j and 6l were found to exhibit appreciable analgesic activity, and 6b, 6g and 6k showed good antibacterial activity against Gram (+) bacteria: B. subtilis, S. aureus, S. epidermis, and Gram (-) bacteria: E. coli, P. aeruginosa and K. pneumoniae. Compound 6b showed overall better anti-inflammatory, analgesic and antibacterial activity among the synthesized compounds. The results of the present study could be helpful for the designing of effective anti-inflammatory, analgesic and antibacterial agents.
Agid:
6198424