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Chemical constituents of the roots of Codonopsis lanceolata

Du, Young Eun, Lee, Jin Su, Kim, Hye Mi, Ahn, Ji-Hye, Jung, In Ho, Ryu, Jong Hoon, Choi, Jung-Hye, Jang, Dae Sik
Archives of pharmacal research 2018 v.41 no.11 pp. 1082-1091
Codonopsis lanceolata, alkaloids, cell viability, chemical composition, humans, inhibitory concentration 50, macrophages, medicinal properties, neoplasm cells, nitric oxide, ovarian neoplasms, phenolic compounds, polyacetylenes, roots, saponins
A new phenylpropanoid (1), a new alkaloid (11), and a new natural polyacetylene (17), together with nine phenolic compounds (2–10), five alkaloids (12–16), three polyacetylenes (18–20), three triterpenoidal saponins (21–23), one phenylethanoid glycoside (24), and three hexyl glycosides (25–27) with previous known structures, were isolated from the roots of Codonopsis lanceolata. All of the isolates 1–27 were evaluated for their inhibitory effects on LPS-induced nitric oxide (NO) production in RAW 264.7 macrophages and cell viability in A2780 human ovarian cancer cells. Among the isolates, lancemasides A and B have a significant inhibitory effect on the production of NO in RAW264.7 cells (IC₅₀ values < 50 μM). In A2780 cells, lancemaside A exhibited the most potent inhibitory effect on cell viability. This is the first report on the pharmacological activities of lancemaside B (22).