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Protective potential of Opuntia microdasys flower decoction on fructose-alloxan-induced diabetic rats on kidney and pancreas: chemical and immunohistochemical analyses

Author:
Chahdoura, Hassiba, Khlifi, Aida, Lamine, Jihéne Ben, Ziani, Borhane Eddine Cherif, Adouni, Khawla, El Bok, Safia, Haouas, Zohra, Neffati, Fadoua, Zakhama, Abdelfattah, Flamini, Guido, Achour, Lotfi
Source:
Environmental science and pollution research international 2018 v.25 no.33 pp. 33645-33655
ISSN:
0944-1344
Subject:
Opuntia, alloxan, amylases, animal disease models, catalase, creatinine, flowers, fructose, glycemic effect, glycohemoglobin, immunohistochemistry, kidneys, lipid peroxidation, males, metformin, noninsulin-dependent diabetes mellitus, oral administration, oxidative stress, pancreas, pancreatic diseases, protective effect, rats, renal failure, superoxide dismutase, thiobarbituric acid-reactive substances, triacylglycerol lipase, urea, uric acid, Tunisia
Abstract:
Diabetes is a serious condition that is linked to the development of oxidative stress causing among many other effects, kidney failure and pancreatic disorders. However, traditional plant-based remedies can be considered an alternative to diabetes healing. In this context, this study was oriented towards evaluating the protective effect of the flowers of Opuntia microdasys Lehm. collected in Tunisia at a biochemical and histological level on kidneys and pancreas of a type 2 diabetic rats. Renal and pancreatic toxicities were induced in diabetic male Wistar rats by fructose alloxan. Diabetic rats were treated with an extract obtained from flowers collected at post-flowering stage (OFP) (100 and 200 mg kg⁻¹ bw) and metformin (100 mg kg⁻¹ bw) for 28 days. Oral administration of OFP at 200 mg kg⁻¹ bw showed significant reduction of the uric acid, urea, creatinine, amylase, lipase, and glycated hemoglobin (HbAlc). The levels of SOD, CAT, and GPₓ were increased, while protein carbonyls and lipid peroxidation TBARS levels were reduced in the kidney and pancreas. The altered kidney and pancreas histology were restored in rats treated with OFP. Thus, the present study demonstrated that OFP has antihyperglycemic activity in fructose-alloxan-induced diabetic rats.
Agid:
6207490