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Inhibitory Effect of fermented pectin on key metabolic enzymes associated with diabetes, obesity; and Liver-Kidney tissues toxicities

Hamden, Khaled, Boujibiha, Mohamed Ali, Abdeljelil, Nouha ben, Njima, Manel, Achour, Lotfi
Bioactive carbohydrates and dietary fibre 2018 v.16 pp. 82-89
alanine transaminase, animal disease models, aspartate transaminase, blood serum, carboxylic ester hydrolases, creatinine, diabetes, dietary fiber, enzyme activity, heart, histology, hyperglycemia, hyperlipidemia, intestines, kidneys, lactate dehydrogenase, liver, obesity, pancreas, pectins, rats, sugars, therapeutics, tissues, urea
Consumption of a high fat and sugar diets induced serious disorders and diseases such as obesity, hyperlipidemia and type2 diabetes. Food fiber exerts various beneficial effects in health. The present study evaluate the effect of Soluble Fermentable Dietary Pectin (SFDP) in high-fat/fructose diet (HFFD) induced obesity, hyperlipidemia and hyperglycemia. The findings indicate that administration of SFDP to HFFD rats improved body weight by decreasing lipase activity in intestine and pancreas by 34% and 22% respectively as compared to untreated HFFD rats; consequently decrease in body weight by 19%; and also decrease in TC and LDL-c and TG rates by 15%, 14%, and 32% and increase in HDL-c by 32%. In addition, consumption of SFDP significantly suppressed α-amylase activity (key enzyme related to hyperglycemia) and this leads to decrease in blood glucose level by 24% than those in the diabetic rats. In addition, SFDP efficiently protected the hepatic and kidney functions observed by the considerable decrease of aspartate and alanine transaminases (AST and ALT) and lactate deshydrogenase (LDH), creatinine (Creat) and urea contents in the serum of diabetic rats. The beneficial effects of SFDP were also evidenced histological study of liver, kidney and heart tissues. Overall, the findings of the present study indicate that SFDP displays a number of promising properties and can used as therapeutic agents in for amelioration of obesity, hyperlipidemia and hyperglycemia.