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Enhancing intracellular microRNA imaging: a new strategy combining double-channel exciting single colour fluorescence with the target cycling amplification reaction
- Zhang, Keying, Song, Shuting, Yang, Lin, Min, Qianhao, Wu, Xingcai, Zhu, Jun-Jie
- Chemical communications 2018 v.54 no.93 pp. 13131-13134
- chemical compounds, chemical reactions, color, fluorescence, fluorescent dyes, image analysis, microRNA, neoplasm cells
- A microRNA (miRNA) fluorescence (FL) nanoprobe based on PDA-UCNPs@FAM-LLD@AuNPs was developed, which exhibited an enhanced signal for imaging intracellular miRNA by combining double-channel exciting single colour FL (DCESCF) with the target cycling amplification reaction. Through this strategy, normal cells and cancer cells could be successfully discriminated.