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A highly selective and sensitive fluorescent probe for simultaneously distinguishing and sequentially detecting H₂S and various thiol species in solution and in live cells

Author:
Qiao, Dan, Shen, Tangliang, Zhu, Mengyuan, Liang, Xiao, Zhang, Lu, Yin, Zheng, Wang, Binghe, Shang, Luqing
Source:
Chemical communications 2018 v.54 no.94 pp. 13252-13255
ISSN:
1364-548X
Subject:
chemical reactions, fluorescent dyes, hydrogen sulfide, mammals, mitochondria, thiols
Abstract:
A novel dual-channel fluorescent probe (NCR) based on differences in reactivity among H₂S, Cys/Hcy, and GSH was rationally designed for simultaneously distinguishing and sequentially sensing H₂S, Cys/Hcy, and GSH using two emission channels, which also demonstrated that NCR can be used for targeting mitochondria in mammalian cells.
Agid:
6219405