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Hemostatic effect of novel carbon dots derived from Cirsium setosum Carbonisata

Author:
Luo, Juan, Zhang, Meiling, Cheng, Jinjun, Wu, Shuhong, Xiong, Wei, Kong, Hui, Zhao, Yan, Qu, Huihua
Source:
RSC advances 2018 v.8 no.66 pp. 37707-37714
ISSN:
2046-2069
Subject:
Cirsium arvense, blood coagulation, carbon quantum dots, coagulation, fibrinogen, hemorrhage, liver, mice, tail, toxicity, water solubility
Abstract:
In this study, for the first time, we discovered novel water-soluble carbon dots (CDs, named CSC-CDs) from aqueous extracts of Cirsium setosum Carbonisata (CSC), which were uniform in size and possessed a nearly spherical shape, and the CDs exhibited low toxicity against RAW 264.7 cells by CCK-8 assay. Most importantly, tail hemorrhaging and liver hemorrhaging experiments showed that CSC-CD-treated mice had significantly shorter bleeding times than normal saline-treated mice. Coagulation assays suggested that the CSC-CDs could stimulate the extrinsic blood coagulation system and activate the fibrinogen system. These results suggested that the CSC-CDs have a remarkable hemostatic effect. The study provides evidence to support the further investigation of the considerable potential of carbon dots.
Agid:
6219439