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Cancer Theranostic Applications of Albumin-Coated Tobacco Mosaic Virus Nanoparticles

Author:
Pitek, A. S., Hu, H., Shukla, S., Steinmetz, N. F.
Source:
ACS applied materials & interfaces 2018 v.10 no.46 pp. 39468-39477
ISSN:
1944-8252
Subject:
Tobacco mosaic virus, animal models, biocompatibility, breast neoplasms, coatings, disease course, doxorubicin, drug therapy, gadolinium, image analysis, ligands, magnetic resonance imaging, molybdenum, nanoparticles, patients, prostatic neoplasms, serum albumin
Abstract:
Nanotechnology holds great promise in cancer drug delivery, and of particular interest are theranostic approaches in which drug delivery and imaging are integrated. In this work, we studied and developed the plant virus tobacco mosaic virus (TMV) as a platform nanotechnology for drug delivery and imaging. Specifically, a serum albumin (SA)-coated TMV formulation was produced. The SA coating fulfils two functions: SA provides a stealth coating for enhanced biocompatibility; it also acts as a targeting ligand enabling efficient tumor accumulation of SA-TMV versus TMV in mouse models of breast and prostate cancer. We demonstrate drug delivery of the chemotherapy doxorubicin (DOX); TMV-delivered DOX outperformed free DOX, resulting in significant delayed tumor growth and increased survival. Furthermore, we demonstrated the ability of SA-coated TMV loaded with chelated Gd(DOTA) for magnetic resonance imaging detection of tumors. In the future, we envision the application of such probes as theranostic, where first imaging is performed to assess whether the nanoparticles are effective at targeting a particular patient tumor. If targeting is confirmed, the therapeutic would be added and treatment can begin. The combination of imaging and therapy would allow to monitor disease progression and therefore inform about the effectiveness of the drug delivery approach.
Agid:
6220012