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Antimicrobial and Antileishmanial Activities of Diterpenoids Isolated from the Roots of Salvia deserta

Jennifer Búfalo, Charles L. Cantrell, Melissa R. Jacob, Kevin K. Schrader, Babu L. Tekwani, Tatyana S. Kustova, Abbas Ali, Carmen S. F. Boaro
Planta medica 2016 v.82 no.1-2 pp. 131-137
Aedes, Leishmania donovani, Salvia, Staphylococcus aureus, Streptococcus iniae, antibacterial properties, antibiotic resistance, antifungal properties, antiparasitic properties, bacteria, bioassays, diterpenoids, fish, inhibitory concentration 50, larvae, larvicides, methicillin, roots, synergism
Four diterpenes with biological activity were isolated from Salvia deserta roots. Taxodione was considered leishmanicidal, with IC50 value of 0.46 µg/mL against Leishimania donovani and also exhibited antifungal and antimicrobial activities. Ferruginol displayed the greatest activity (24-h IC50 1.29 mg/L) against the fish pathogenic bacteria Streptococcus iniae. The crude extract fraction which contained the isolated compounds 7-O-acetylhorminone and horminone showed stronger in vitro antibacterial activity (1.28 µg/mL for Staphylococcus aureus and 1.12 µg/mL for methicillin-resistant S. aureus - MRSA) than the compounds tested alone. 7-O-Acetylhorminone and horminone exhibited a synergistic effect against MRSA (FIC 0.2 µg/mL), and horminone had better activity against S. aureus with respect to other compounds isolated from S. deserta roots. In larvicidal bioassays, these extracts and isolated pure compounds did not show any activity at the highest dose of 125 ppm against 1-d-old Aedes. aegypti larvae.