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Nuclear Factor Erythroid 2-Related Factor 2 Activating Triterpenoid Saponins from Camellia japonica Roots

Author:
Ko, Kiwon, Wahyudi, Lilik D., Kwon, Yong-Soo, Kim, Jung-Hwan, Yang, Heejung
Source:
Journal of natural products 2018 v.81 no.11 pp. 2399-2409
ISSN:
1520-6025
Subject:
Camellia japonica, antioxidant activity, genes, humans, keratinocytes, neoplasms, oxidative stress, reactive oxygen species, response elements, roots, transcription factors, triterpenoid saponins
Abstract:
Oxidative stress due to the presence of excess reactive oxygen species may cause cancers, aging, and many other conditions. Nuclear factor erythroid 2-related factor 2 (Nrf2) may control abnormal oxidative stress as a transcription factor by inducing antioxidant-related genes via antioxidant response elements (AREs) in the gene promoters. The 11 triterpenoid saponins (1–11) isolated from Camellia japonica roots were tested for ARE-luciferase activity and Nrf2 accumulation in human keratinocytes (HaCaT cells). The ARE-luciferase activity was significantly increased by compounds 1–11 (25 μM) as a result of nuclear Nrf2 accumulation in the cells. Thus, these compounds may contribute to the induction of Nrf2 activity against oxidative damage in cells.
Agid:
6225214