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Halogenated Meroditerpenoids from a South Pacific Collection of the Red Alga Callophycus serratus

Author:
Woolner, Victoria H., Gordon, Rose M. A., Miller, John H., Lein, Matthias, Northcote, Peter T., Keyzers, Robert A.
Source:
Journal of natural products 2018 v.81 no.11 pp. 2446-2454
ISSN:
1520-6025
Subject:
Rhodophyta, cell lines, cytotoxicity, inhibitory concentration 50, neoplasm cells, Tonga
Abstract:
A detailed examination of the red alga Callophycus serratus collected in Tonga led to the isolation of six new halogenated meroditerpenoids: callophycol C (1), callophycoic acid I (2), iodocallophycols E (3) and F (4), iodocallophycoic acid B (5), and callophycoic acid J (6). Of these, compounds 3–5 are new iodinated additions to the growing family of Callophycus meroditerpenoids. The relative configurations of compounds 1–6 were deduced by analyses of 1D NOE data and ¹H–¹H scalar coupling constants, and 3–6 are proposed to differ from the closely related compounds reported in the literature, iodocallophycoic acid A and iodocallophycols A–D. Iodocallophycol E (3) exhibited moderate cytotoxicity against the promyelocytic leukemia cell line HL-60 with an IC₅₀ value of 6.0 μM.
Agid:
6225219