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Hoshinoamides A and B, Acyclic Lipopeptides from the Marine Cyanobacterium Caldora penicillata

Author:
Iwasaki, Arihiro, Tadenuma, Takato, Sumimoto, Shimpe, Shiota, Ikuma, Matsubara, Teruhiko, Saito-Nakano, Yumiko, Nozaki, Tomoyoshi, Sato, Toshinori, Suenaga, Kiyotake
Source:
Journal of natural products 2018 v.81 no.11 pp. 2545-2552
ISSN:
1520-6025
Subject:
Cyanobacterium (genus), Plasmodium falciparum, cytotoxicity, human cell lines, inhibitory concentration 50, lipopeptides, parasites, spectral analysis
Abstract:
Hoshinoamides A (1) and B (2), new acyclic lipopeptides, were isolated from the marine cyanobacterium Caldora penicillata. Their structures were elucidated by spectroscopic analyses and degradation reactions. Hoshinoamides A (1) and B (2) did not exhibit any cytotoxicity against HeLa cells at 10 μM, but inhibited the in vitro growth of the malarial parasite Plasmodium falciparum (IC₅₀ = 0.52 and 1.0 μM, respectively).
Agid:
6225232