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A Steroid-Type Antioxidant Targeting the Keap1/Nrf2/ARE Signaling Pathway from the Soft Coral Dendronephthya gigantea

Author:
Wu, Jianzhang, Xi, Yiyuan, Huang, Lili, Li, Ge, Mao, Qiqi, Fang, Chengyan, Shan, Tizhuang, Jiang, Wei, Zhao, Min, He, Wenfei, Dong, Jianyong, Li, Xiubao, Qiu, Peihong, Yan, Pengcheng
Source:
Journal of natural products 2018 v.81 no.11 pp. 2567-2575
ISSN:
1520-6025
Subject:
antioxidants, corals, signal transduction, spectral analysis, steroids, South China Sea
Abstract:
Four new steroids, named 7-dehydroerectasteroid F (1), 11α-acetoxyarmatinol A (2), 22,23-didehydroarmatinol A (3), and 3-O-acetylhyrtiosterol (4), together with 11 previously described analogues, were isolated from a South China Sea collection of the soft coral Dendronephthya gigantea. The structures of the new steroids were elucidated by comprehensive spectroscopic analysis and by comparison with previously reported data. Compound 1 showed potent protection against H₂O₂-induced oxidative damage in neuron-like PC12 cells by promoting nuclear translocation of Nrf2 and enhancing the expression of HO-1. 1 represents the first steroid-type antioxidant from marine organisms.
Agid:
6225235