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Bisleuconothines B–D, Modified Eburnane–Aspidosperma Bisindole Alkaloids from Leuconotis griffithii

Author:
Alfarius Eko Nugroho, Wenjia Zhang, Yusuke Hirasawa, Yiming Tang, Chin Piow Wong, Toshio Kaneda, A. Hamid A. Hadi, Hiroshi Morita
Source:
Journal of natural products 2018 v.81 no.11 pp. 2600-2604
ISSN:
1520-6025
Subject:
bark, humans, indole alkaloids, inhibitory concentration 50, lungs, monoterpenoids, neoplasm cells, nuclear magnetic resonance spectroscopy
Abstract:
Three new bisindole alkaloids, bisleuconothines B–D (1–3), were isolated from the bark of Leuconotis griffithii. Their structures were elucidated by 1D and 2D NMR spectroscopy and DFT calculations. Bisleuconothine B (1) is the first monoterpene indole alkaloid dimer featuring bridges between both C-16–C-10′ and C-2–O–C-9′. All compounds were deemed noncytotoxic (IC₅₀ > 10 μM) when tested against A549 human lung adenocarcinoma cells.
Agid:
6225237