Bisleuconothines B–D, Modified Eburnane–Aspidosperma Bisindole Alkaloids from Leuconotis griffithii
- Source:
- Journal of natural products 2018 v.81 no.11 pp. 2600-2604
- ISSN:
- 1520-6025
- Subject:
- bark, humans, indole alkaloids, inhibitory concentration 50, lungs, monoterpenoids, neoplasm cells, nuclear magnetic resonance spectroscopy
- Abstract:
- Three new bisindole alkaloids, bisleuconothines B–D (1–3), were isolated from the bark of Leuconotis griffithii. Their structures were elucidated by 1D and 2D NMR spectroscopy and DFT calculations. Bisleuconothine B (1) is the first monoterpene indole alkaloid dimer featuring bridges between both C-16–C-10′ and C-2–O–C-9′. All compounds were deemed noncytotoxic (IC₅₀ > 10 μM) when tested against A549 human lung adenocarcinoma cells.
- Agid:
- 6225237
- https://doi.org/10.1021/acs.jnatprod.8b00749