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Bisleuconothines B–D, Modified Eburnane–Aspidosperma Bisindole Alkaloids from Leuconotis griffithii
- Nugroho, Alfarius Eko, Zhang, Wenjia, Hirasawa, Yusuke, Tang, Yiming, Wong, Chin Piow, Kaneda, Toshio, Hadi, A. Hamid A., Morita, Hiroshi
- Journal of natural products 2018 v.81 no.11 pp. 2600-2604
- bark, humans, indole alkaloids, inhibitory concentration 50, lungs, monoterpenoids, neoplasm cells, nuclear magnetic resonance spectroscopy
- Three new bisindole alkaloids, bisleuconothines B–D (1–3), were isolated from the bark of Leuconotis griffithii. Their structures were elucidated by 1D and 2D NMR spectroscopy and DFT calculations. Bisleuconothine B (1) is the first monoterpene indole alkaloid dimer featuring bridges between both C-16–C-10′ and C-2–O–C-9′. All compounds were deemed noncytotoxic (IC₅₀ > 10 μM) when tested against A549 human lung adenocarcinoma cells.