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Protein measurements in venous plasma, earlobe capillary plasma and in plasma stored on filter paper

Author:
Siart, Benjamin, de Oliveira, Felipe Marques Souza, Shen, Qiujin, Björkesten, Johan, Pekar, Thomas, Steinborn, Ralf, Nimmerichter, Alfred, Kamali-Moghaddam, Masood, Wallner, Bernard
Source:
Analytical biochemistry 2019 v.566 pp. 146-150
ISSN:
0003-2697
Subject:
biomarkers, blood, chemical species, males, proteins
Abstract:
In this study, levels of inflammatory protein biomarkers in venous plasma, plasma derived from capillary blood from the earlobe, and capillary plasma stored as dried plasma spots (DPS) were compared. Samples from 12 male individuals were assessed with a panel of 92 inflammation-related proteins using multiplex proximity extension assay. Correlations between sample types varied greatly between analytes. A high correlation of ρ > 0.8 was observed between capillary plasma and DPS for 32 analytes. At this level of correlation, 13 analytes correlated between venous and capillary plasma and 5 analytes in the comparison of venous blood with DPS.
Agid:
6225273