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Hydrodynamic delivery of IL-38 gene alleviates obesity-induced inflammation and insulin resistance

Xu, Keye, Sun, Jun, Chen, Sisi, Li, Yuan, Peng, Xiao, Li, Mingcai, Li, Yan
Biochemical and biophysical research communications 2019 v.508 no.1 pp. 198-202
adipose tissue, anti-inflammatory activity, chemokine CCL2, gene transfer, genes, high fat diet, hydrodynamics, inflammation, insulin resistance, interleukin-1beta, interleukin-6, lipid content, liver, mice, obesity, plasmids, tissue weight, weight gain
Obesity is associated with a chronic inflammatory response. Interleukin (IL)-38 is a poorly characterized cytokine of the IL-1 family with anti-inflammatory activity. The role of IL-38 in obesity-induced inflammation and insulin resistance remains unknown. In this study, we investigated the effects of IL-38 expression by hydrodynamic-based gene delivery on high-fat diet-induced obesity in mice. Transfer of plasmid DNA encoding IL-38 reduced weight gain, liver fat content, adipose tissue weight, and obesity-induced insulin resistance compared with administration of a control plasmid. Moreover, IL-38 gene delivery inhibited the production of inflammatory mediators including IL-1β, IL-6, and monocyte chemotactic protein-1. These results suggest that IL-38 is a potential new target for the treatment of obesity.