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Protective effects of a Lachnum polysaccharide against liver and kidney injury induced by lead exposure in mice

Author:
Hou, Guohua, Surhio, Maheen Mahwish, Ye, Hongling, Gao, Xiaoming, Ye, Ziyang, Li, Jinglei, Ye, Ming
Source:
International journal of biological macromolecules 2019 v.124 pp. 716-723
ISSN:
0141-8130
Subject:
Lachnum, antioxidants, apoptosis, body weight, caspase-3, functional foods, glutathione peroxidase, histopathology, kidneys, lead, liver, mice, polysaccharides, protective effect, proteins, tissues, toxicity, transforming growth factor beta 1
Abstract:
This study was designed to investigate the liver and kidney protective efficacy of a Lachnum polysaccharide (LEP) against Pb-induced toxicity in mice. The results showed that LEP decreased the Pb-induced bodyweight loss and organ index. Moreover, biochemical analysis showed that treatment of LEP could improve antioxidant status (CAT, GSH-Px and MDA) and the injury of tissues (liver and kidney). In addition, the histopathological observations indicated that LEP could attenuate liver and kidney cell injury induced by Pb. For further studies, key proteins involved in hepatic and kidney apoptosis, including cleaved caspase-3, Bax, Bcl-2, TGF-β1 and α-SMA, were quantified. The present findings demonstrated that LEP is strongly effective in protecting against the liver and kidney injury induced by Pb. We hope this research can offer a theoretical base for development of polysaccharide based on nutraceutical food in future.
Agid:
6226918