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Stimulus-activatable echogenic maltodextrin nanoparticles as nanotheranostic agents for peripheral arterial disease

Jung, Eunkyeong, Lee, Jeonghun, Jeong, Lipjeong, Park, Sanghun, Lee, Moungyoung, Song, Chulgyu, Lee, Dongwon
Biomaterials 2019 v.192 pp. 282-291
animal models, biomarkers, carbon dioxide, endothelial cells, fluorescence, half life, hydrogen peroxide, image analysis, ischemia, maltodextrins, muscles, nanoparticles, therapeutics
Reactive oxygen species (ROS) are closely related with various pathological disorders. Therefore, real-time detection of ROS is essential for understanding the procedure of diseases and diagnosing the accurate lesion sites. Hydrogen peroxide (H2O2) accounts for a large portion of ROS and has a longer half-life than other ROS, which makes it a highly promising diagnostic and therapeutic biomarker. In this work, we developed H2O2-activatable CO2 bubble generating indocyanine green-loaded boronated maltodextrin (ICG-BM) nanoparticles for imaging and therapy of peripheral arterial disease. ICG-BM nanoparticles displayed increasing fluorescence, ultrasound and photoacoustic signals in H2O2-triggered manners and exerted significant anti-inflammatory and proangiogenic effects in H2O2-stimulated vascular endothelial cells. In mouse models of hindlimb ischemia, ICG-BM nanoparticles also showed H2O2-triggered amplification of fluorescence, ultrasound and photoacoustic signals in the ischemic hindlimb muscles. ICG-BM nanoparticles also significantly reduced the level of overproduced H2O2 and exerted highly potent anti-inflammatory and proangiogenic activities in the ischemic tissues. We therefore believe that pathological stimulus-activatable echogenic ICG-BM nanoparticles provide a new avenue for imaging and treatment of peripheral arterial disease.