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A Reappraisal of Circulating Fetal Cell Noninvasive Prenatal Testing
- Rezaei, Meysam, Winter, Marnie, Zander-Fox, Deirdre, Whitehead, Clare, Liebelt, Jan, Warkiani, Majid Ebrahimi, Hardy, Tristan, Thierry, Benjamin
- Trends in biotechnology 2019 v.37 no.6 pp. 632-644
- DNA, blood, chlorofluorocarbons, cost effectiveness, diagnostic sensitivity, high-throughput nucleotide sequencing, microarray technology, screening
- New tools for higher-resolution fetal genome analysis including microarray and next-generation sequencing have revolutionized prenatal screening. This article provides commentary on this rapidly advancing field and a future perspective emphasizing circulating fetal cell (CFC) utility. Despite the tremendous technological challenges associated with their reliable and cost-effective isolation from maternal blood, CFCs have a strong potential to bridge the gap between the diagnostic sensitivity of invasive procedures and the desirable noninvasive nature of cell-free fetal DNA (cffDNA). Considering the rapid advances in both rare cell isolation and low-input DNA analysis, we argue here that CFC-based noninvasive prenatal testing is poised to be implemented clinically in the near future.