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Fabrication of polydopamine-based layer-by-layer nanocomposites for combined pH-sensitive chemotherapy and photothermal therapy

Author:
Ma, Hongchao, Li, Shuo, Zhang, Hao, Wei, Yanhui, Jiang, Lei
Source:
Colloids and surfaces 2019 v.561 pp. 332-340
ISSN:
0927-7757
Subject:
absorbance, adverse effects, alginates, biocompatibility, colloids, doxorubicin, drug therapy, electrostatic interactions, energy conversion, nanocomposites, neoplasms, photothermotherapy, quaternary ammonium compounds, schiff bases
Abstract:
The combined therapeutic strategy have aroused significant interest in cancer therapy due to its enhanced treatment efficacy and reduced side effects. This paper describes the combined chemo- and photothermal therapy of cancer based on PDA@(PDDA-ADA)3-Dox nanocomposites. Polydopamine (PDA) serves not only as photothermal agent with strong near infrared absorbance and high energy conversion efficiency, but also as a core material to carry multilayer films formed by alternatively deposition of positively charged poly(diallyldimethylammonium chloride) (PDDA) and negatively charged alginate dialdehyde (ADA) through layer-by-layer (LBL) method. Doxorubicin hydrochloride (Dox) was loaded to the PDA@(PDDA-ADA)3 nanoplatform via Schiff base bond and electrostatic interaction. The fabricated PDA@(PDDA-ADA)3-Dox nanocomposites exhibit outstanding pH-sensitive drug release, good biocompatibility and high photothermal conversion efficiency. These features make them achieve excellent anticancer therapeutic efficacy by combined chemo- and photothermal therapy. This work points that the PDA-based nanoplatform can be a universal scaffold for cancer treatment.
Agid:
6229672