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Ishigadine A, a new canthin-6-one alkaloid from an Okinawan marine sponge Hyrtios sp.

Author:
Takahashi, Hideaki, Kurimoto, Shin-ichiro, Kobayashi, Jun'ichi, Kubota, Takaaki
Source:
Tetrahedron letters 2018 v.59 no.51 pp. 4500-4502
ISSN:
0040-4039
Subject:
Porifera, arginine, chemical reactions, chemical structure, cytotoxicity, histidine, indole alkaloids, mice, neoplasm cells, spectral analysis, tryptophan
Abstract:
A new indole alkaloid with the canthin-6-one skeleton, ishigadine A, has been isolated from an Okinawan marine sponge Hyrtios sp. The structure of ishigadine A was elucidated on the basis of spectroscopic analyses. Ishigadine A is a new canthin-6-one alkaloid possessing a hydroxy group, a 1,3-dimethyl-4-methylthioimidazolium, and a 1-propylguanidine. Ishigadine A is the third canthin-6-one alkaloid from sponges. Ishigadine A might be generated from l-arginine, l-histidine, and l-tryptophan. Ishigadine A exhibited moderate cytotoxicity against L1210 murine leukemia cells.
Agid:
6232162