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Krebs Cycle Reimagined: The Emerging Roles of Succinate and Itaconate as Signal Transducers

Author:
Murphy, Michael P., O’Neill, Luke A.J.
Source:
Cell 2018 v.174 no.4 pp. 780-784
ISSN:
0092-8674
Subject:
metabolites, oxidative phosphorylation, signal transduction, tricarboxylic acid cycle
Abstract:
Krebs cycle intermediates traditionally link to oxidative phosphorylation whilst also making key cell components. It is now clear that some of these metabolites also act as signals. Succinate plays an important role in inflammatory, hypoxic, and metabolic signaling, while itaconate (from another Krebs cycle intermediate, cis-aconitate) has an anti-inflammatory role.
Agid:
6233045