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Krebs Cycle Reimagined: The Emerging Roles of Succinate and Itaconate as Signal Transducers
- Murphy, Michael P., O’Neill, Luke A.J.
- Cell 2018 v.174 no.4 pp. 780-784
- metabolites, oxidative phosphorylation, signal transduction, tricarboxylic acid cycle
- Krebs cycle intermediates traditionally link to oxidative phosphorylation whilst also making key cell components. It is now clear that some of these metabolites also act as signals. Succinate plays an important role in inflammatory, hypoxic, and metabolic signaling, while itaconate (from another Krebs cycle intermediate, cis-aconitate) has an anti-inflammatory role.