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Enhancing Therapy: It’s about Time
- Brown, Myles
- Cell 2018 v.174 no.4 pp. 771-772
- diet, diurnal variation, drugs, genes, lipid metabolism, obesity, therapeutics
- How diet and obesity impact diurnal changes in physiology remains unclear. In this issue of Cell, Guan et al. report that diet-induced obesity modulates the activity of circadian gene enhancers including those regulating lipid metabolism and show that the efficacy of lipid-lowering drugs depends on the time of administration.