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Mechanobiology of Protein Droplets: Force Arises from Disorder
- Welsh, Timothy J., Shen, Yi, Levin, Aviad, Knowles, Tuomas P.J.
- Cell 2018 v.175 no.6 pp. 1457-1459
- biophysics, chromatin, condensates, droplets, forces, optogenetics, separation
- The use of optogenetic approaches has revealed new roles for intracellular protein condensates described in two papers in this issue of Cell (Bracha et. al., 2018; Shin et al., 2018). These results show that growing condensates are able to exert mechanical forces resulting in chromatin rearrangement, establishing a new role for liquid-liquid phase separation in the mechanobiology of the cell.