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Platelet for drug delivery
- Lu, Yifei, Hu, Quanyin, Jiang, Chen, Gu, Zhen
- Current opinion in biotechnology 2019 v.58 pp. 81-91
- adhesion, blood platelets, carcinogenesis, coatings, drug delivery systems, drugs, engineering, hemostasis, inflammation, metastasis, neoplasms, tissue repair
- Platelets play a vital physiological role in hemostasis, inflammation and tissue regeneration, which are associated with wound healing as well as cancer development and metastasis. These years, a variety of platelet-mediated drug delivery approaches have been developed due to their unique properties, such as quick replenishment and site-specific activation/adhesion. In this Current Opinion, focuses are put on strategies leveraging the physiological functions of platelets for the design of drug delivery systems, including platelet engineering, platelet hitchhiking, membrane coating, synthetic platelet fabrication and platelet-triggered drug release for different applications.