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Antifungal Activity of a Synthetic Cationic Peptide Against the Plant Pathogens Colletortrichum graminicola and Three Fusarium Species

Johnson, Eric T., Evans, Kervin O., Dowd, Patrick F.
Plant Pathology Journal 2015 v.31 no.3 pp. 316-321
Colletotrichum, Fusarium graminearum, Fusarium oxysporum, antifungal properties, cell membranes, conidia, corn, crops, disease control, fungi, growth retardation, leaves, lipid bodies, plant pathogens, synthetic peptides, tissues
A small cationic peptide (JH8944) was tested for activity against a number of pathogens of agricultural crops. JH8944 inhibited conidium growth in most of the tested plant pathogens with a dose of 50 µg ml 1, although one isolate of Fusarium oxysporum was inhibited at 5 µg ml 1. Most conidia of Fusarium graminearum were killed within 6 hours of treatment with 50 µg ml 1 of JH8944. Germinating F. graminearum conidia required 238 µg ml 1 JH8944 for 90% growth inhibition. The peptide did not cause any damage to tissues surrounding maize leaf punctures when tested at a higher concentration of 250 µg ml 1 even after 3 days. Liposomes consisting of phosphatidylglycerol were susceptible to leakage after treatment with 25 and 50 µg ml 1 of JH8944. These experiments suggest this peptide destroys fungal membrane integrity and could be utilized for control of crop fungal pathogens.