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Fighting Cancer Using an Oncofetal Glycosaminoglycan-Binding Protein from Malaria Parasites
- Agerbæk, Mette Ø., Bang-Christensen, Sara, Salanti, Ali
- Trends in parasitology 2019 v.35 no.3 pp. 178-181
- chondroitin sulfate, diagnostic techniques, malaria, neoplasm cells, neoplasms, parasites, therapeutics
- Malaria research has led to the discovery of oncofetal chondroitin sulfate, which appears to be shared between placental trophoblasts and cancer cells and can be detected by the evolutionary refined malaria protein VAR2CSA. Interestingly, using recombinant VAR2CSA to target oncofetal chondroitin sulfate shows promise for novel cancer diagnostics and therapeutics.