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3,4-Dicaffeoylquinic acid protects human keratinocytes against environmental oxidative damage

Author:
Hyun, Yu Jae, Piao, Mei Jing, Kang, Kyoung Ah, Ryu, Yea Seong, Zhen, Ao Xuan, Cho, Suk Ju, Kang, Hee Kyoung, Koh, Young Sang, Ahn, Mee Jung, Kim, Tae Hoon, Hyun, Jin Won
Source:
Journal of functional foods 2019 v.52 pp. 430-441
ISSN:
1756-4646
Subject:
DNA damage, air pollution, apoptosis, coffee beans, environmental impact, humans, keratinocytes, lipid peroxidation, oxidative stress, particulates, protective effect, reactive oxygen species, ultraviolet radiation
Abstract:
Skin is exposed to several harmful environmental effects including ultraviolet B (UVB) and air pollution, the most harmful component of which is particulate matter (PM). Damaging effects of UVB and PM include the generation of cellular reactive oxygen species (ROS), lipid peroxidation, protein carbonylation, DNA damage, and apoptosis. A compound with the potential to protect the skin against environmental oxidative damage is 3,4-dicaffeoylquinic acid (DQA), an antioxidant found in plant matter, including the coffee bean. In this study, we investigated the protective effects of DQA against UVB- and PM-induced oxidative cell damage in cultured human keratinocytes (HaCaT). We demonstrated that UVB, and PM with a diameter <2.5 µm (PM2.5), induced cellular damage via oxidative stress, and this was mitigated by the antioxidative action of DQA.
Agid:
6234852